These records are predominantly correspondence, financial accounts, minutes and reports relating to all aspects of the Company's business. The Company was one of the main slave traders of the period and many of the volumes record the purchase and sale of slaves, the rate of mortality among slaves on the voyages, accounts of the treatment of runaway slaves, contracts for the supply of slaves to North and South America and the Caribbean, records of the arrival of slaves in London including their number, gender and physical condition and the employment of slaves on the Company's forts. Other records include:
- Detailed inventories of the forts, listing employees by name, and containing financial accounts of the cost of maintaining and defending the forts
- Records of the movement of company stock
- Accounts of trades in rum, cotton, sugar, indigo, tobacco and textiles
- Contracts of employment naming individuals and listing their positions and salaries
- Journals kept by traders recording experiences at sea
- Registers of ships' passes detailing each voyage with the ship's name, the captains, tonnage, number of guns and crew members
- Correspondence on a wide variety of subjects including relations with the indigenous peoples, questions of policy, diplomatic relations with the Dutch, piracy and details of the running of the forts
- Reports on the misconduct of employees, attacks on company property and how money supplied by Parliament was spent
- Customs registered recording goods on ships leaving Barbados bound for Britain and North America
- Lists of auctions of property belonging to deceased employees of the Company
- Registers listing the original members of the Company
The forts to which many of the records relate are: James Fort, on the River Gambia, Dixcove, Anamaboo, Succonda (or Succondee), Commenda, Cape Coast Castle, Fort Royal, Apollonia, Tantumquerry, Winnebah (or Winnebagh) and Accra, all on the Gold Coast, Williams Fort at Whydah and Sherbrow on York Island, Sierra Leone.
In addition there are separate volumes of name indexes (called 'alphabets'). Most of these refer to the accounts ledgers but some relate to other financial records and to the letter books.
Please note that some of the records in this series are unsorted.